Lupus kidney

Lupus kidney
overview: systemic lupus erythematosus (SLE) is a kind of infringement of systemic connective tissue of autoimmune diseases, multiple organ lesions often involving many system. Lupus kidney is the most common form of systemic lupus erythematosus (SLE) visceral damage, the severity of the kidney disease change directly affects the prognosis of SLE. Lupus kidney is systemic lupus erythematosus (sle) after a long illness development of glomerular lesions.
Performance: LN usually damage glomerular, renal tubule and renal interstitium.
1. The whole body to perform intermittent fever, zygomatic erythema (butterfly erythema), discoid lupus, allergies, mouth ulcers, arthritis, serositis, nervous system abnormalities (tic or mental illness).
2. Kidney performance： simple hematuria and proteinuria, hematuria, proteinuria, edema, lumbar acid, or high blood pressure, namely nephritis sample performance; A large number of proteinuria, hypoalbuminemia, edema, namely nephrotic syndrome "appearance; Hematuria and proteinuria with kidney function decline sharply, a radical nephritis; Renal interstitial lesions; Chronic renal failure.
Reason:
1, lupus kidney as the basis, immune disorders including lupus patients with renal abnormalities of the body's immune tolerance, B cell function, T cell dysfunction and abnormal cytokines.
2, the onset of lupus kidney link - immune complex deposition.
Lupus kidney disease in the process, will produce a variety of their own organizations including the nucleus, cell membrane, cytoplasm tissue elements and a variety of autoantibodies. Of antinuclear antibodies (ANA) is the most important, its pathogenesis, diagnosis of systemic lupus erythematosus (sle) and disease has played a key role. Patients with systemic lupus erythematosus (sle) complicated with kidney disease change, there will be a antigen antibody immune complex in vivo and in situ immune complex deposition in the glomerular, thus cause damage to the kidney function, is with lupus nephritis.
Prevention:
1. Pay attention to physical factors.
2. Active treatment of virus infection.
3. Pay attention to drug toxicity.
4. Avoid exposure to the sun.
Treatment:
1. The treatment principle of SLE remains unknown disease is a kind of reasons, the main purpose of treatment is to control the activity of LN, protect kidney function and delay the development of renal tissue fibrosis.
2. Light SLE: normal function of target organs or stable with lupus nephritis, discretionary with non-steroidal anti-inflammatory drugs or antimalarial drugs, may use in the short-term, small doses of corticosteroids such as prednisone 20 to 40 mg/d), when it is necessary to add with immune inhibitors.
3. The heavy SLE : the important target organs appear obvious damage with lupus nephritis, glomerulonephritis does not relieve, the accelerated glomerular nephritis, nephrotic syndrome patients, should be given standard hormone therapy (prednisone 1 mg/kg/d) and immunosuppressant treatment, for acute life-threatening hormone shock treatment shall be given to the patients with severe lupus (a prednisolone 0.5 ~ 1.0 g/d). When the inefficiency of the above method or condition the heavier, plasma exchange therapy may be considered. Accompanied by severe acute renal insufficiency, heart failure, severe high blood capacity should be emergency dialysis, to make it past the danger period.
4. Treatment of end-stage: end-stage with lupus nephritis is treated like chronic renal failure.
http://m.kidneyhospital.org/